The fisher VS 47 thing

47 has it easy because Fisher cant walk very fast when he has his guns out.

Now..

Anyone vs Solid Snake...

One entire TF2 Team (i.e. 1 person per class) vs....wait for it....the Combine. Now THAT is a story someone needs to write! :D

Another good thing maybe the F.E.A.R. Pointman vs The Master Chief or Gordon Freeman. I've actually written this up a bit in a piece of fiction which also involved a FEAR REV-6 vs Nemesis, from Resident Evil 3 <_<

Another potential candidate is Gordon Freeman vs the Avatar from System Shock 2

HOWEVER, there is one fight that we would ALL pay to see without question. Ladies and Gentlemen, I bring to you:

GLaDOS vs SHODAN

Almightyjoe:
Dog wins, he finds a strider and hits Goliath with it

FF12's Vaan v Sora from kingdom hearts

the above conjures many adored memories of watching dexters lab, where dexter and (name forgotten) exchanged slaps for 2 minutes straight

The guy's name is Mandark.
I agree, battle of the girly-men would be awesome.

in double agent sam has a map that updates in real time just like 47's also his gun is fully automatic as well. 47 what does he have in all seriousness? he has nothing but a couple guns which are equaled by the sc-20k. sams got stealth up to wazoo he can hide in shadows, vents, rappel and grenade to his hearts content and 47 wouldnt even see him coming

I'm sorry, but I'm going to have to point something out about this.
You're forgetting that Agent 47 is actually physically superior to most humans, due to his creation. Hence his ability to soak up bullets, jog forever, and (in the original game) rip out a mounted turret from the ground and use it as a normal gun.

As a side note, yay, my first post. *waves flag*

*coughs*
Vincent Valentine v.s. Master Chief

My prediction? Valentine.

Balrog vs Vanessa

And please don't forward me your Mugen videos.

Archimonde from Warcraft III vs. the people on your team in FEAR. I just want those two to DIE!!!

a cool one would be Sephiroth vs. Kratos

another cool one is Laura Croft vs. John Woo

Ratchet & Clank vs. Gordon Freeman
Chuck Norris vs. Jesus (There's no contest; guess who wins.)
Sly Cooper vs. Altaïr.
Jesus vs. Anybody else, just to see them get utterly ahnailated.

Link vs Roy or Isaac (Fire Emblem/Golden Sun respectively). Probably Link, but Roy's abilities in SSBM and Isaac's djinn have to be a factor.

Agent 47 vs Naked Snake - You have Agent 47's badass European no-bullshit efficiency, coupled with the fact that he's a clone, versus Snake's camo and combat skills.

The Cobras vs The Incredibles and Batman - Classic superpower fight. The Cobras were one of the best villians I've ever seen, seriously. They were brilliant. Pitch them against the five Incredibles and a guy with a Batmobile and you'd have one helluva fight.

Volgin vs Ganondorf - Homosexual Russian Colonel with an electric personality (har har) up against one evil badass. Sounds fun.

Just thought of this after another thread:

The Crusader vs Frank Horrigan

Weighted Companion Cube (Portal)

vs.

Cardboard Box (Metal Gear)

No matter who wins, bitter tears of grief will be shed on the loser's behalf.

Ryu Hayabusa (Ninja Gaiden (Xbox)) vs. Hotsuma (Shinobi (PS2))

end_boss:
Just thought of this after another thread:

The Crusader vs Frank Horrigan

I know the Crusader but who the Hell is Frank?

Razzle Bathbone:
Psychic duel:
Nick Scryer from Psi-Ops vs. Razputin from Psychonauts
Go Raz!

Dimensional shifter duel:
April "The Longest Journey" Ryan vs. Chell "Portal" Whatzername
An interesting battle; each fighter would struggle to gate the other into an impossible situation. I think April's got the edge because although either of them can pass unharmed through a portal, only April can pass through a shift and survive.

Stealther duel:
Solid Snake (Metal Gear) vs. Garrett (Thief)
Close call here. Snake's tougher and he's got the advantage in firepower, but Garrett is sneakier, and he's got that detatchable eye camera.

Bloodsucker duel:
Blood Rayne vs. Smiling Jack ("Vampire the Masquerade: Bloodlines")
Jack tears her to pieces. He also makes disparaging remarks about her incredibly stupid wardrobe and laughs a lot.

Bleeping Freaking Brilliant analysis. Congrats

Ness vs. any GTA main character.

Round 1: The GTA dude runs through Vice City with the minigun. Ness jumps out from round a corner and attacks. The GTA guy begins to aim but is owned by PK Flash.

THE END

Is this only playable characters? If not, i would like to see Gordon Freeman fight Gman.
That would probably be the most unfair battle ever, unless Gordon receives some help from the vortigaunts. :O

Haliwali:

end_boss:
Just thought of this after another thread:

The Crusader vs Frank Horrigan

I know the Crusader but who the Hell is Frank?

Basically, a bitg mutant encased in a giant suit of power armor, which is a bitch to try and crack.

Solid Snake VS Sam Fisher (A fight to the death I say!)
Hitman VS Max Payne
Tommy Vercety VS John Vattic
Barney (HL2) VS Chell

I have a block in my mind right now that prevents thinking. I will post when I have destroyed it with a hammer.

Razzle Bathbone:
Weighted Companion Cube (Portal)

vs.

Cardboard Box (Metal Gear)

No matter who wins, bitter tears of grief will be shed on the loser's behalf.

LMFAO, you are now my best friend.

Tommy Vercetti (GTAVC) vs Claude Speed (GTAIII)

Wait, sorry, it's obvious Tommy would destroy Claude.

Kratos vs Teen Titans

Get it? Clash of the titans! Hahaha...I suck.

Edit: Also add in...

Demyx (KHII) vs Nikki (Chrono Cross)

battle of the guitars.

Gordan Freeman vs. Chuck Norris vs. Weighted Companion Cube vs. Jesus

Companion cube > all

brandon148:
Gordan Freeman vs. Chuck Norris vs. Weighted Companion Cube vs. Jesus

...I think the universe would explode.
Now that I think about it, it would only explode once MC got in on the fight.

Also: Chuck Norris' beard vs. Captain Price's Moustache.

Nemesis vs Birkin.

Darth Vader and Mitsurugi. Wait a second... They're doing that one! Heyoooh!

Noriko versus Kratos on Skinamax!

I second that notion! But with less Kratos and more Chun-li!

How about Mario and Bowser? It's about time those two appear in a game together...

I'm a fan of The Nameless One (from Planescape:Torment) versus Arthas (before he became the Lich King). I vote Nameless One. :D

For real nerds: Ribald Barterman versus Deidre Galloway (if you know these people... kudos folks).

Oh, and in Freeman versus Master Chief, I vote Freeman.

nilpferdkoenig:
In the Freeman vs. Master Chief debate I would have to go with the MC, simply because he is being backed by earth and Freeman doesn't really have much except for some scrawny rebells, Alyx and Dog.

In a 1v1 fight I'm not sure because Freeman could just pick up the MC with the Gravity Gun since the MC isn't really completly biological anymore.

Fetch Dog, fetch. *Master Chief crushed* Good dog.

Samus Aran vs. Mega Man
Snake vs. the guy form bioshock
kirby vs. Metal Gear Rex
the Heavy vs. minigun boss from Metal Gear Solid
Leon from RE4 vs. someguy not a zombie

Companion Cube VS Master Chief

Easy.

Prince of Persia vs. Altair (you'd have people fighting on the walls and everything... Damned if that wouldn't be cool.)

Sephiroth vs. Master Chief (I really just like watching the green bastard die.)

Grunt vs. a GLADos turret

Tonberry vs. a pair of Hunters

Cactaur vs. Sonic

Dante vs. the girl from Heavenly Sword. (This one would be particularly cool in my opinion.)