Oh you know them, those girls who kick our asses, and then make us weep for mercy, rules are, they cant have stared in games that were created solely to exploit women. Aka Dead or alive extreme, sorry girls.

With out further adieu i will submit the females who kick all ass, and what games they were in.

The Exile - Yes, confirmed by Lucas to have been female while Revan was male, though she is a chooseable sex, the true sex of this woman was female. She could awaken people to the force and also make them follow her without knowing it due to her huge Charisma - Knights of the Old Republic 2

Miku - From Fatal Frame, this girl stood up to a whole mansion full of ghosts and ghools, and stayed sane enough to either save her brother, or watch him sacrifice himself - Fatal Frame

Miyu/Mayu - These two count as 1 because their twins, yes, twin girls and you play as them both, Same concept cept they took on a whole town of ghosts - Fatal Frame II: Crimson Butterfly

Meryl - She kicks all ass and she will take down your name, and if your lucky, she will kick the shit into your as before makeing you marry her. Metal Gear Solid, and Metal Gear Solid IV

Samus - How could nintendo's number 1 femme fatal not make this list, i dont even have to list the individual games she was in, just know she was trained by the chozo so even without her suit, she can still kick your ass with a beam whip - Metroid Series + Smash Bros Series

Finally

Kos-Mos - This Android from the future is also the Wife of the Messiah, She was Mary Magdeline, i know many argue the point where she isnt the wife of jesus, just a follower, but i believe she was something more as the only female Apostile of Christ. Kos-mos was a battle android and single handedly took out 1 million aliens...or human souls who refuse to accept the love of Jesus in the afterlife and linger on being Pure salt like creatures who only kill. - Xenosaga Series

Choose now!

A femme fatale is a woman who defeats people with her hawtness. I'm not really sure any of these fit the bill. But I voted for the Exile, because she's awesome.

Samus and Meryll are both not Femme Fatales.

Crap, wrong thread.

poleboy:
A femme fatale is a woman who defeats people with her hawtness.

Yeah. So naturally, Ashelin from Jak 2 is the best candidate.

You didnt include Imoen? HOW COULD YOU.

Courtesy of wikipedia:

A femme fatale (plural: femmes fatales) is an alluring and seductive woman whose charms ensnare her lovers in bonds of irresistible desire, often leading them into compromising, dangerous, and deadly situations. She is an archetypal character of literature and art. Her ability to entrance and hypnotize her male victim was in the earliest stories seen as being literally supernatural, hence the most prosaic femme fatale today is still described as having a power akin to an enchantress, vampire, female monster or demon. The ideas involved are closely tied to fears of the female witch.

I think, by name, Vamp is a Femme Fatale.

A "femme fatale" is a woman who lures men into men into making dangerous mistakes with their beauty and sexual charms. Think Delilah, Mata Hari, Kathleen Turner in Body Heat.

I don't think any of these apply.

I don't care what femme fatale actually means. Any poll with all female characters, Samus should win.

*Runs to make poll titled "Biggest Loser Female Character"* :D