How to Beat the Mindflayer in FF7 Rebirth (Biological Intel Head Case)

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The Mindflayer is a classic fantasy-type enemy that also makes an appearance in Final Fantasy 7 Rebirth. Fighting it via the Classified Intel mission is easy enough, but there’s another encounter with it that’s way more infuriating. Here’s how to beat the Mindflayer in Biological Intel: Head Case in FF7 Rebirth.

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FF7 Rebirth Biological Intel Head Case Mindflayer Strategy and Tips

Biological Intel: Head Case is easily one of the most frustrating missions you’ll encounter in FF7 Rebirth. Not only is the Mindflayer itself a pain to deal with, the adds and your party AI also add another layer of annoyance to everything.

First, here are some quick tips to help you out:

  • Cast Sleep on the Varghidpolis as soon as the fight starts.
  • Use all of your weapon and Synergy abilities on the Mindflayer to Pressure and Stagger it.
  • Kill the Mindflayer as quickly as you can with your strongest abilities, though you may want to consider reapplying Sleep on the other Varghipods before this.
fighting the mindflayer in biological intel: head case in ff7 rebirth

The goal of this fight is to kill the Mindflayer as quickly as possible to prevent it from using its Mind Blast ability, and to take it down before the Varghidpolis. The problem is, your AI party members have a tendency to go for the adds instead of the Mindflayer, making it near impossible to Stagger it right away. Because of this, you’ll want to cast Sleep on the adds as soon as you can, and this will prevent your party members from targeting them, and they’ll instead focus their efforts on the Mindflayer.

Once you do this, things should become exponentially easier, as you’ll be able to Pressure and Stagger the Mindflayer easily. Right before the Mindflayer is Staggered, consider reapplying Sleep to the other enemies if you feel like enough time has gone by, and this will ensure that your party members don’t get distracted while wailing on the Mindflayer.

Best Party Comp for Biological Intel Head Case Mindflayer

The party setup I used for Biological Intel: Head Case was Yuffie, Cloud, and Barret. I had Yuffie as my party leader, and the reason for this is that the other two characters don’t really have AoE abilities that might accidentally damage and kill the adds.

First, I had Magnify and Sleep Materia on Yuffie, and I started the fight by quickly casting Sleep on the Varghidpolis as mentioned above. After that, I had to aggro the Mindflayer and attempt to drag it as far away from the adds as possible, as there’s still a chance that your party members will try to attack them even while they’re asleep.

While you have the Mindflayer dragged away, beat it down with your abilities to Stagger it, then kill it quickly. You’ll want to use Cloud’s Braver ability, as well as all of Barret’s Overcharge abilities to take it down efficiently.

Alternatively, if you have them, you can also equip the Malboro Orb on Yuffie and have her use Enfeeblement on the Varghidpolis if Sleep isn’t working. By turning the adds into Toads, the AI is also less likely to target the adds during the fight.

Down below, we’ve also listed some Materia orbs you should absolutely bring with you into the fight:

  • 3-star Poison
  • ATB Boost
  • Time

Poison Materia allows you to cast Poison and Bio on the Mindflayer, which it is susceptible to, allowing you to whittle its health down passively. The ATB Boost Materia charges up your ATB gauge quickly, while Time Materia allows you to cast Haste, which will also speed up your ATB charge rate.

With the latter two Materia in particular, you’ll be able to cast Sleep on the Varghipods pretty much as soon as the battle begins, allowing you and your teammates to focus on the Mindflayer after that. After you’ve cleared the fight, you’ll learn Mind Blast, which is one of the more powerful enemy skills in the game.

And that’s how to beat the Mindflayer in Biological Intel: Head Case in FF7 Rebirth.


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Author
Zhiqing Wan
Zhiqing is a History undergrad from the National University of Singapore. She started playing video games in 1996 when her dad introduced her to Metal Gear Solid, Silent Hill, and Resident Evil -- and the rest, as they say, is history. When she's not obsessing over Elden Ring and Dark Souls lore theories, you can find her singing along loudly and badly to Taylor Swift's latest bops. Formerly the Reviews Editor at Twinfinite, she joined the Escapist team in 2024. You can reach her at [email protected].