Win8 PC game help?

I'm not really sure where to post this I mean it's kinda a game problem, but not really... I need advice more than anything. xP

Anyways, When I am playing most games full screen it wont lock the mouse or rather the Win8 Overlays still pop up like the start button, and the side panel. So I mouse over the place it should be, those pop up I click on them while trying to shoot someone or something and am tabbed out. I'm sure others had to have this problem, and I think I could find a fix if I knew how to word it right. No matter what I search I don't quite get what im looking for. It's Kinda related but not really. I'm out of ideas... can't even replay ME3 cause I keep getting tabbed out and dying. So yeh, any help would be nice.

 

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