Ahhh... Eternal Darkness, what a game.
Good list, I think the Deadpool "Boss Fight" from Marvel Ultimate Alliance 2 deserved a mention though!
Paper Mario: The Thousand Year Door has some of the best fourth-wall breaking scenes ever.
"Hey, you! On the other side of the screen! I know that you know who I am, but no telling Mario!"
"...Um, who are you talking to?"
Only one other person in this whole thread mentioned Earthbound?
I feel ashamed i went and Downloaded I Dont Want to Wait by Paula Cole after watching this.....
Lol @ the way she runs
#1 definitely deserved it.
ME2 had some references to other games but it didn't actually break the fourth wall. Still, pretty sweet.
The psych mantis thing was the best i tottally freaked me out the first time. "HOW DID YOU KNOW?! GET OUT OF MY HEAD!"
Eternal Darkness was pretty scary too.
I was totally panicking to the batman scare crow "glitch", so awesome.