Either Girl Genius or Schlock Mercenary would make awesome breakout properties. On the one side you've got a sociopathic amorph, a troop of mercenaries, an idiot savant demo expert, and SCIENCE!. On the other you have a slightly* megalomaniac mad scientist, minions, an intelligent yet schizophrenic castle, and SCIENCE!^2.
*Only when compared to every other mad scientist in the world in question.
Occult Mayhem? Nazi punching? Lovecraftian horrors? SCIENCE?
Dammit, I was gonna say Atomic Robo. But seriously, how can you get more awesome than a robot made by Nicola Tesla who fights evil, and Nazis, and time-travelling dinosaurs?