The second Pokémon Mystery Dungeon game. First one came damn close too as a matter of fact.

I've always found it astonishing how I've yet to find a single review that so much as mentions the story (other than the central premise).

Silent Hill 2 - the lead up to the ending(s), just the overall experience was draining and emotional. I always used to wonder why it had such upbeat music as it's main theme but it just kind of goes with it now.

On the way to the last boss in shadow of the colossus, I knew it was going to happen at some stage, I'd read all about it, I'd seen all the spoilers, but it was still the saddest moment in any game I've ever played. I was also really moved after killing the first colossus, and just kind of stood there thinking about what I'd just done.

also several points in FF7 brought me close, when redXIII learns about his dad, when cait sith takes one for the team, when I realized what clouds deal was. But in no way was I even remotely sad when aeris got herself stabbed, I have hated her as a character from the first time I fell through the church roof. "will you be my bodyguard?" no, piss off.

Rawne1980:
Duke Nukem Forever.

I cried after realising i'd waited 14 years and wasted Ł40 on a game that will end up propping up a broken legged coffee table next to my PC.

Lol, loved this answer.

But in all seriousness.

*Clears throat*

The ending cinematic of Ratchet & Clank: A Crack in Time.

You really need to have played all the games to feel it...

Mass Effect 3, Mordin on Tuchanka. He sang God Dammit! I knew it was coming but still... damn.

The Night Angel:
The end of Red Dead Redemption. I defy someone not to at the end of that game. It really makes you feel.

Yeah, a friend was watching me play it. He laughed when tears started rolling down my face. I made him a bet that if he played the game and didn't cry I'd give him a fiver. Bastard didn't play the game...

Gears 3 Spoiler:

Portal 2 Spoiler:

AC Revelations Spoiler:

Valkyria Chronicles was the last one that actually made me tear up, not the cliche'd ending but in the middle.

I felt like crying in Minecraft just there when an Enderman randomly materialised in front me and kindly charged forward, sending me plummeting down a giant pit to my doom. It's all right, I wans't really in any way attached to my armour/inventory anyway.

Captcha : Geez Louise! That's a bit of a coincidence actually, as the post I just read was about Gears 3.

I still have yet to cry from a traditional video game.

That said, Katawa Shoujo made me a great deal of cry manly tears. That story hit me like a ton of bricks.

Hmmm... You know what? The last part of Cave Johnson's speech in Portal 2.

Once he get passed the part with the lemons and quiets down and Glados says goodbye. It was very sad.

(Also, J.K. Simmons kicks ass)

The true ending of Asura's Wrath

God damn...

I always feel a welling up when a location is revealed to me. Leaving the Vault in FO3, seeing the strip lit up at night from a distance in New Vegas, My first steps through Rapture. Plus the good ending for Bioshock had me feeling like I had saved my soul

Red Dead Redemption. When John watches his family ride off, then sacrifices himself to make sure they get away safely, I got a little misty-eyed.
Gears of War 2. Dom and Maria's reunion was great. At least until Dom saw what Maria had become and had to put her down.
Mass Effect 3. Seeing Mordin die just hurt. He was one of my favorite characters from ME2, but it had to be him. Someone else might have gotten it wrong. Then when Legion sacrificed himself to free the geth, he proved he did, in fact, have a soul. Thane's death didn't really hit me until Kolyat told Shepard that Thane's dying prayer was for him. And how can I forget Shepard and Garrus' final conversation? Hearing "There is no Shepard without Vakarian" gets me every time.

Oh man, Mass Effect 3 with Thane's death. And Mordin's death when doing Renegade. Almost with Mordin's death doing Paragon too. Luckily, I saved the Geth and the Quarians.

Red Dead Redemption, for obvious reasons.

Oh, and Lonesome Road's ED-E. I already loved ED-E before, but after hearing those recordings, I just grew even more attached.

The Opening cinematic to Wrath of the Lich King.

The final cut scene of Mafia.

Only one game: Silent Hill: Shattered Memories.

I'd suggest playing the full game though, it really is a great experience.

Or if you don't feel like playing it...

9 hours 9 persons 9 doors. The submarine ending. If you've played it you know what I mean.

Losing my Pokemon Yellow save to a glitch when I was seven. As heartbreaking then as it is now. I cried over my Wartortle, floating somewhere in some cybernetic Lethe, for days. :'(

deserteagleeye:

VMK:
*Spoilers ahead (probably)*
First of all, death of Mordin and Thane in ME3. I just loved those guys.
Next:Shadow of Colossus. Not that I cried, but I felt some sort of crying feeling every time I killed the Colossi.
But the most tear-bringing moment for me is ending of Final Fantasy X. Six times I've completed it, six times I cried.

deserteagleeye:
That one scene in Persona 4 and the ending. I wouldn't dare spoil it.

I played the game. Which scene are you talking about?

By play, did you mean you beat it? If so,

Spoiler: Click to ViewPHA+VGhlIHNjZW5lIHdpdGggTmFuYWtvIGluIHRoZSBob3NwaXRhbC4gV2hlbiBzaGUgZGllZC4gVGhhdCB3YXMgc29vb29vIHNhZCBmb3IgbWUuPC9wPg==

I gotta say that the animated series really caught that moment. It was damn good.

Oh, that... Good thing she actually didn't.

The only time I've ever really gotten close to crying was in Risen, when those lizards butcher the dog. Why is it the god damn dog?! They could have killed the two human hunters, but noooo...

EDIT: Oh, I can actually think of a human example here. Again, I came pretty close to tearing up. In the first Witcher game, at the lakeside village. That entire storyline involving the two sisters.. yeah, after that had finished and the lakeside daytime soundtrack kicks in, it just made me think in-depth on the whole situation and just how depressing it was. And..

I never cried because of a game but I got fairly depressed with Heavy Rain.

In the Dragon Age: Origins after you light the beacon and Teyrn Loghain retreats leaving all the Grey Wardens by themselves and then seeing Duncan die made me cry for a good 3 minutes.

Mass Effect 3: I messed up the situation on Rannoch: I didn't have enough Paragon skill and I lost all of the awesome characters. I had nightmares about it too.
Pokemon Mystery Dungeon: I played this a long time ago and I can't remember the details... Something sad happened to a Grovyle but I honestly haven't a clue what it was.

The ending of ME3 made me horribly depressed for a while.

Mass Effect 3

Halo Reach

I haven't actually cried because of a game (haven't cried in a while at all actually...) but Mordin in ME3 and the end of Portal 2 were the closest. Portal 2 just overwhelmed me with emotions all at the same time.

I hear you-I basically bawled throughout all of ME3-and at the end-since I play a fem-shep with Kaiden, I about cried myself to sleep that night. I know-so pathetic-but that game is so amazing-it's hard to say goodbye!

I don't think I've actually cried in a game, but a few scenes did have me misty-eyed.

Red Dead Redemption has been mentioned. As has inFamous 2's blue ending.

But one that was strangely effective was Medal of Honor, the recent reboot.

1080bitgamer:
I only recently acquired and played through Super Metroid, and after playing as Samus Aran for such an extensive amount of time, when it was time to end the game, I literally cried. I could play the game again, but it wouldn't be the same as the first time I saw her spare that Metroid.

So to you I say, which characters made you cry in a video game and for what reason?

wow. I thought I was the only one. :)

Super Metroid was the big one. The ending got me every time when I was a kid. Other than that, Defcon really moved me the first time I played it, before I got into the "gamer mindset" about it.