You won't need to use Ubisoft's proprietary gaming platform Uplay for the PC version of South Park: The Stick of Truth.
While we heard earlier today that Respawn Entertainment's upcoming Titanfall will require Origin, EA's proprietary gaming platform to play, South Park: The Stick of Truth developer Obsidian has come out to confirm that the upcoming RPG will not require Uplay for the PC version of the game.
"No, Uplay will not be featured in SP:SOT," stated the official Obsidian Twitter account, in response to a question over whether or not the Steam version of the game will require Uplay to run.
Ubisoft's Uplay is one of the newest players in digital storefronts/game managers. Like Steam and Origin before it, it allows players to buy and play various Ubisoft titles. A major distinction between it and competitor Origin is that you can actually purchase non-Ubisoft titles from the Uplay store, and the amount of games that actually require the client to be installed is quite low.
So you can go ahead and pre-order the game on Steam without having to worry about installing another game manager. Good to hear!