The next Mass Effect remains vague, but BioWare shares some insight into what's coming.
At EA's press conference, BioWare talked about Dragon Age: Inquisition and what's next in the Mass Effect universe. They were vague on Mass Effect details, but they confirmed that the stories would take place in new regions of space with full worlds to explore. There was also a roaring Krogan - well, it looked like a Krogan - on a destroyed world similar to Tuchanka.
It may be vague, but hearing Mass Effect music with these new images and concepts is likely going to be my favorite moment from E3.